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Clomid is a favored fertility drug for women with the conditions described below, as it is low cost, is easily self-administered orally, has few contraindications (reasons it can’t be taken), and has only one known drug interaction (see Precautions, below). Clomid is also occasionally used to treat certain fertility problems in men, such as low sperm count (oligospermia), poor sperm quality, or poor sperm motility (movement). Additionally, it is prescribed off-label for male hypogonadism (diminished gonad function, AKA interrupted puberty) as an alternative to testosterone replacement therapy.
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What Is Clomid?
Clomid is the trade name for clomifene or clomiphene citrate. It is a selective estrogen receptor modulator (SERM). It is used to induce ovulation and to reverse anovulation (lack of ovulation) and oligoovulation (irregular or infrequent ovulation). It is often prescribed for women who have stopped ovulating due to PCOS (polycystic ovary syndrome). PCOS is found in approximately 6-7% of women of reproductive age. Anovulation and oligoovulation make about 25% of all female infertility problems.
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What is Clomid prescribed for?
Clomid is often prescribed to regulate ovulation prior to artificial insemination or intrauterine insemination for women who have had irregular menstrual cycles. Clomid is also frequently given prior to assisted reproductive technology (ART) treatment, such as IVF (in vitro fertilization) or GIFT (gamete intrafallopian transfer) to produce multiple eggs for these procedures.
Women with luteal-phase deficiency can also benefit from Clomid therapy. Luteal-phase deficiency means ovarian follicles (eggs) produce a poor corpus luteum, the progesterone-secreting temporary structure that helps an egg during implantation phase. Clomid has been shown to improve the quality of the corpus luteum by encouraging a higher progesterone concentration prior to and during ovulation.
Sometimes physicians use Clomid in what is known as a clomiphene challenge test. This is used to check a patient’s ovulation and determine egg quality, also known as ovarian reserve. In a clomiphene challenge test, Clomid is taken for five days early in the menstrual cycle. This elevates the follicle-stimulating hormone (FSH) level. An FSH level that returns to normal right away is a sign of healthy ovarian reserve, while an FSH level that remains elevated is a sign of decreased ovarian reserve. The patients in the latter category can save themselves months or even years of fertility treatments that will only end in frustration and despair at not conceiving. Women who have a decreased ovarian reserve often have success giving birth using donor eggs.
Clomid is used with reservation in women who have unexplained fertility issues. While it has stimulated ovulation that led to conception in some patients, there is limited clinical data supporting its use without a known cause of infertility. Many practitioners prescribe Clomid therapy in combination with intrauterine insemination (IUI) for increased success rates in women with infertility of unknown cause. Nevertheless, Clomid therapy alone represents a viable alternative for many women, as it is noninvasive, low cost, and relatively easy to use when compared to other fertility drugs and procedures. Some physicians are comfortable allowing patients to try Clomid for several cycles to see if it brings results, as long as their patients have no known contraindications or experience no extreme adverse reactions to the drug.
What are other names for Clomid
Clomid is also known by its generic names, clomifene and clomiphene, as well as Serophene, another trade name.